Extract your game to a folder. Open the .cue file in a text editor and verify the .bin filename matches exactly. Then restart the emulator.
If all else fails, the core might be corrupted. epsxe core stopped check the section 316 full
To fix "ePSXe core stopped," switch your to Direct3D and clear your Memory Card files. If the issue persists, verify that your Game ISO is not corrupted. Fixing the “ePSXe Core Stopped – Check Section
If the problem persists, and re-setup ePSXe from scratch. Run a different PS1 game